|HEAT - Helicobacter Eradication Aspirin Trial - Helicobacter Eradication to Prevent Ulcer Bleeding in Aspirin Users: A Large Randomised Controlled Trial||
Aspirin use is widespread and increasing in the elderly and this has led to a rise in gastro-intestinal bleeding, due to the use of long-term aspirin. This trial is based on evidence that ulcer bleeding in aspirin users occurs predominantly in people infected with the bacterium H. pylori.
The research has three objectives:
1) Medical – will a one week course of H. Pylori eradication using aspirin reduce the incidence of subsequent adjudicated peptic ulcer bleeding resulting in hospitalisation?
2) Economic – has a positive monetary benefit.
3) Methodological – to establish a methodology for larger simple outcomes studies using electronically extracted Primary care follow-up data, to reduce costs.
|Narratives of Health||This study aims to find out more about abdominal aortic aneurysms (AAA). This is a condition where the main artery in the body swells up increasing the risk of it bursting as a result. Whilst AAA can be found when small there is no treatment for them other than high-risk surgery. Recently a national screening programme has been started for AAA and through this programme, patients with AAA and those found not to have AAA will be recruited into this study. Study participants will have blood and urine samples taken at several time points as well as being asked to fill in questionnaires about how they feel and their general health. These samples and the information from the questionnaires will be used to determine what genes and proteins are associated with AAA and the growth of AAA. Also, how patients feel about having an AAA and how this affects their wellbeing will be studied. Through this study more detailed information about why and how aneurysms occur and grow will be found out, potentially leading to a drug treatment for small aneurysms - and avoiding the need for surgery in those with AAA|